There are some basic rule of thumb design tactics when setting up the layout and structure of your website. If you follow these basic principles you’ll be much further ahead.
Depending on the purpose of your website, the main page should be the place that links off to further information and resources regarding your chosen topic as well as answers the key questions and demands you’re audience will be thinking.
By creating a clear call to action on this page you will have the ability to engage the user with your chosen topic be it selling or not.
Heat maps have proven that the general user brings the cursor from left to right and back to the middle and down.. creating a clear path for you to follow when laying your pictures, text and links down.
Another proven subject is clean and clear text without the addition of too much information. Cheers!